KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K12
All Species:
24.55
Human Site:
S25
Identified Species:
45
UniProt:
Q12852
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q12852
NP_006292.2
859
93219
S25
V
S
T
L
S
E
A
S
M
R
K
L
D
P
D
Chimpanzee
Pan troglodytes
XP_509099
871
93967
S25
V
S
T
L
S
E
A
S
M
R
K
L
D
P
D
Rhesus Macaque
Macaca mulatta
XP_001105474
890
96134
S25
V
S
T
L
S
E
A
S
M
R
K
L
D
P
D
Dog
Lupus familis
XP_857182
860
93116
S25
V
S
T
L
S
E
A
S
M
R
K
L
D
P
D
Cat
Felis silvestris
Mouse
Mus musculus
Q60700
888
96066
S25
V
S
T
L
S
E
A
S
M
R
K
L
D
P
D
Rat
Rattus norvegicus
Q63796
888
96289
S25
V
S
T
L
S
E
A
S
M
R
K
L
D
P
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422689
966
107967
V67
M
D
N
M
S
S
P
V
T
A
A
V
L
T
S
Frog
Xenopus laevis
A7J1T0
961
107551
K31
V
D
T
I
Q
E
D
K
D
Y
R
V
D
Y
G
Zebra Danio
Brachydanio rerio
NP_996977
856
94429
P25
T
T
P
L
S
D
P
P
F
C
R
P
D
P
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q95UN8
1161
128942
Q26
E
E
Q
Q
L
Q
Q
Q
Q
Q
Q
Q
Q
L
E
Honey Bee
Apis mellifera
XP_397605
895
101116
C50
I
F
T
N
S
M
L
C
I
Q
E
E
L
G
Q
Nematode Worm
Caenorhab. elegans
O01700
928
103465
D38
S
T
V
V
L
S
P
D
G
S
E
L
V
T
Q
Sea Urchin
Strong. purpuratus
XP_795085
943
105022
T41
P
A
R
V
T
V
T
T
N
P
E
H
E
K
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.7
95.2
97.4
N.A.
92.5
91.7
N.A.
N.A.
52.3
51.8
65.4
N.A.
24
38.4
29
38.6
Protein Similarity:
100
95.8
95.6
98.5
N.A.
93.8
93.1
N.A.
N.A.
62.5
63.1
74
N.A.
38.4
52.8
44.9
52.8
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
6.6
26.6
26.6
N.A.
0
13.3
6.6
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
26.6
46.6
53.3
N.A.
26.6
40
26.6
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
0
47
0
0
8
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
8
0
8
0
0
0
0
0
% C
% Asp:
0
16
0
0
0
8
8
8
8
0
0
0
62
0
47
% D
% Glu:
8
8
0
0
0
54
0
0
0
0
24
8
8
0
16
% E
% Phe:
0
8
0
0
0
0
0
0
8
0
0
0
0
0
8
% F
% Gly:
0
0
0
0
0
0
0
0
8
0
0
0
0
8
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% H
% Ile:
8
0
0
8
0
0
0
0
8
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
8
0
0
47
0
0
8
0
% K
% Leu:
0
0
0
54
16
0
8
0
0
0
0
54
16
8
0
% L
% Met:
8
0
0
8
0
8
0
0
47
0
0
0
0
0
0
% M
% Asn:
0
0
8
8
0
0
0
0
8
0
0
0
0
0
0
% N
% Pro:
8
0
8
0
0
0
24
8
0
8
0
8
0
54
0
% P
% Gln:
0
0
8
8
8
8
8
8
8
16
8
8
8
0
16
% Q
% Arg:
0
0
8
0
0
0
0
0
0
47
16
0
0
0
0
% R
% Ser:
8
47
0
0
70
16
0
47
0
8
0
0
0
0
8
% S
% Thr:
8
16
62
0
8
0
8
8
8
0
0
0
0
16
0
% T
% Val:
54
0
8
16
0
8
0
8
0
0
0
16
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
8
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _